Creatinine Clearance & Glomerular Filtration Rate

 

Glomerular Filtration Rate (GFR)

The gold standards in measurement of Glomerular Filtration Rate (GFR) are insulin Clearance or radio isotopic method. Due to practicality, creatinine clearance (Ccr) is commonly used to evaluate GFR.

Diabetes is the leading cause of end-stage renal disease (ESRD). The evaluation of renal function is therefore of critical importance in diabetic subjects. Glomerular filtration rate (GFR) is the best measure of overall kidney function in health and disease. Serum creatinine concentration is also used as an indirect marker of GFR.

Estimation of Creatinine Clearance (Ccr)

Close correlation has been found between urinary creatinine excretion and BCM. It is possible to predict creatinine from BioScan-916 values of BCM and from Plasma creatinine, thus avoiding the necessity of the periodic collection of urine.

Measurements of renal function may be required for several reasons:

  • GFR
  • CCR
  • Min – Max Targets
  • Identify Renal Impairment
  • Monitor Disease Progress
  • Assess baseline measurements prior to starting treatment with certain drugs
  • Monitor disease progress

Disadvantage & Source of Error

1. Precise timed collection of Urine
2. Measurement of Clearances
3. Different formulas to estimate Ccr and GFR from Plasma Creatinine

BioScan was used to estimate GFR in 177 adult renal patients (100 female and 77 males) with different degrees of renal
function.

GFR measured as the renal clearance of 99m TC-DTPA ranged 4.4 – 242 ml/min. A significant linear correlation was found.
GFR was predicted also according to Cockcroft and Gault (CG-GFR) and MDRD formulas (MDRD-GFR)

BioScan-916 is simple and time saving method of avoiding unnecessary collection of urine over 24hrs.
Estimation of GFR is appropriate for the evaluation of renal function and progression of Kidney disease (REFER TO PAPER)